IN THIS STUDY IS REPRESENTED THE RELATIONSHIP BETWEEN SOME OF THE THERMODYNAMIC PROPERTIES OF AMINOACIDS C3NON+1NNH5N+2 (N: 1-10) IN CONTRAST TO SOME TOPOLOGICAL INDICES SUCH AS RANDIC (X), HARARY (H), SCHULTZ (MTI), BALABAN (J) AND WIENER (W) AND MODEL FOR DESIGNING THE QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS BASED ON TOPOLOGICAL INDICES IS PRESENTED THE (QSPR)...

QUADRIDENTATE CHELATING ADSORBENT PLAY A GREAT RULE IN CHEMISTRY AND BIOCHEMISTRY [1]. IN THE PRESENT WORK, WE HAVE USED A NITRILOTRIACETIC ACID (NTA) DERIVATIVE WHICH OCCUPIES FOUR POSITIONS IN THE METAL COORDINATION SPHERE OF. E.G., NI2+ AND CU2+. THE REMAINING TWO LIGAND POSITIONS IN THE OCTAHEDRAL COORDINATION SPHERE ARE DISPOSABLE FOR SELECTIVE COMPLEXATION OF BIORELEVENT MOLECULES SUCH AS AMINOACIDS AND PROTEINS [2]. ...

INTRODUCTION: THE PROCESS IN WHICH HEME MOLECULE BY ITS SUBSTRATE (HYDROGEN PEROXIDE) ARE DEACTIVED AND DESTROYED CALLED THE SUICIDE INACTIVATION PROCESS. IN THESE PROCESSES SUBSTRATE CONCENTRATION SHOULD BE HIGH (3MM).THE CONCENTRATION OF HYDROGEN PEROXIDE DURING THE REACTION REMAIN CONSTANT. THE HEME TIME-DEPENDENT INACTIVATION PROCESS BY HIGH CONCENTRATION OF HYDROGEN PEROXIDE ACTUALLY WILL BE DEPENDENT ON HYDROGEN DONORS CONCENTRATION (GUAIACOL) AND ACTIVATE HEME CONCENTRATION THE PROPER LIGAND AMONG THE AMINOACIDS HISTIDINE, TYROSINE AND CYSTEINE, TYROSINE LIGAND IN THE MOLAR RATIO OF 0.5 (1: 1 COMPLEX) IS A GOOD CANDIDATE FOR OXIDATION REACTIONS HOMOGENEOUS CATALYZED BY HEME.THESE LIGAND WITH INCREASED HEME CATALYTIC ACTIVITY IN SUBSTRATE HIGH CONCENTRATION ACTUALLY SHORTEN THE TIME OF THE REACTION PROCESS AND DECREASE THE SPEED OF INACTIVE PROCESS.

AS WE KNOW THE STRUCTURAL MODIFICATION OF AMINOACIDS AND PEPTIDES IS A CONVENTIONAL METHOD FOR SYNTHESIZING NEW CONJUGATES AS POTENTIAL BIOLOGICALLY ACTIVE COMPOUNDS. TETRAZOLE FRAGMENT IS A STABLE SUBSTITUTE FOR CARBOXYL GROUP AND AMIDE BOND IN MOLECULES OF PEPTIDOMIMETICS AS WELL AS FOR....